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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM4
All Species:
44.55
Human Site:
S357
Identified Species:
70
UniProt:
P33991
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33991
NP_005905.2
863
96558
S357
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Chimpanzee
Pan troglodytes
XP_528129
863
96543
S357
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535063
929
104136
S423
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Cat
Felis silvestris
Mouse
Mus musculus
P49717
862
96718
S356
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Rat
Rattus norvegicus
NP_387500
862
96552
S356
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515513
863
97108
S357
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Chicken
Gallus gallus
XP_424376
859
96866
S353
Q
L
I
K
L
Q
E
S
P
E
D
M
P
A
G
Frog
Xenopus laevis
P30664
863
97105
S357
Q
M
I
K
L
Q
E
S
P
E
D
M
P
A
G
Zebra Danio
Brachydanio rerio
NP_944595
750
84021
L277
M
V
I
R
T
S
Q
L
I
P
E
M
Q
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26454
866
96592
S360
Q
L
V
K
L
Q
E
S
P
D
D
M
A
A
G
Honey Bee
Apis mellifera
XP_624670
636
71159
G163
G
P
Q
L
V
V
W
G
T
N
V
V
I
N
Q
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
Q286
K
G
G
D
K
S
L
Q
G
I
R
T
P
Y
L
Sea Urchin
Strong. purpuratus
XP_801985
910
101460
S402
Q
M
V
K
L
Q
E
S
P
D
D
M
P
A
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
I243
E
H
V
P
K
G
H
I
P
R
S
M
T
V
H
Baker's Yeast
Sacchar. cerevisiae
P30665
933
104985
T402
Q
V
I
K
L
Q
E
T
P
D
F
V
P
D
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
87.6
N.A.
94.9
95.1
N.A.
92.4
86.3
85.7
71.3
N.A.
60.1
42.1
28.1
63.3
Protein Similarity:
100
100
N.A.
90
N.A.
97
97.3
N.A.
96.1
93.1
92.9
78.7
N.A.
77.3
54.3
46.9
76.3
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
93.3
100
13.3
N.A.
73.3
0
6.6
86.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
40
N.A.
93.3
13.3
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.9
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.5
62.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
7
67
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
0
0
0
20
67
0
0
7
0
% D
% Glu:
7
0
0
0
0
0
74
0
0
54
7
0
0
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
7
7
7
0
0
7
0
7
7
0
0
0
0
0
74
% G
% His:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
67
0
0
0
0
7
7
7
0
0
7
0
0
% I
% Lys:
7
0
0
74
14
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
14
0
7
74
0
7
7
0
0
0
0
0
0
7
% L
% Met:
7
54
0
0
0
0
0
0
0
0
0
80
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% N
% Pro:
0
7
0
7
0
0
0
0
80
7
0
0
74
0
0
% P
% Gln:
74
0
7
0
0
74
7
7
0
0
0
0
7
0
7
% Q
% Arg:
0
0
0
7
0
0
0
0
0
7
7
0
0
0
0
% R
% Ser:
0
0
0
0
0
14
0
67
0
0
7
0
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
7
7
0
0
7
7
0
0
% T
% Val:
0
14
20
0
7
7
0
0
0
0
7
14
0
7
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _